PVCC's scenic main campus is located at 501 College Drive in Albemarle County, Virginia. Thousands of students take credit and noncredit classes at this location each semester to meet their career and personal goals. Students must have a permit to park on the main campus. Visitor and handicapped parking is provided. See parking information here. Campus maps can be found here.

The Main Building houses the College's administrative offices, the Business, Technologies and Mathematics Division office, Admissions & Advising Center, Math, Writing and Testing Centers, Cashier's Office,Bookstore, Department of Public Safety & Campus Police, Betty Sue Jessup Library, Bolick Student Center, Career Services, Financial Aid, Fitness Center, Auditorium, classrooms and labs. Mary Baldwin College also has offices in this building. The Technology Wing of the Main Building is home for the Human Resources Office, Computer Lab, IT Services Desk, classrooms and the W. A. Pace Board Room. 

The V. Earl Dickinson Building at the far end of campus is location of the Humanities, Fine Arts and Social Sciences Division office, classrooms, the Dickinson Theatre (Proscenium), Maxwell Theatre (Black Box), PVCC Art Galleries, Lakeside Amphitheater and PVCC Box Office. Tennis courts and playing fields are nearby. The building is named for V. Earl Dickinson, Sr., who dedicated his life to public service, avidly supported education and represented the 56th District (Central Virginia) in the Virginia House of Delegates for 30 years.

The Theodore E. and Patt Hart Keats Science Building is the location of the Health and Life Sciences Division office, classrooms and labs. Old Dominion University has an office and classrooms on the lower level. The building name honors PVCC Alumna Dr. Patt Hart Keats for her donation that creates scholarships for students enrolled in the Radiography Associate of Applied Science Degree program. The gift also honors her late husband Dr. Theodore E. Keats.

PVCC's Workforce Services Division offices and classrooms are located in the Stultz Center for Business and Career Development. The building name honors local citizens Jim and Cynthia Stultz for their support of education and generous donation to PVCC.